Safe Handling of Hazardous Drugs: A Comprehensive Clinical Guideline

Evidence-based guideline for the safe handling, preparation, administration, and disposal of hazardous drugs in healthcare settings, including engineering controls, PPE, and exposure management.

4 articles Updated Mar 2026

Safe Handling of Hazardous Drugs — Part 4: Medical Surveillance, Training, Reproductive Health, and Special Topics

Medical surveillance program design and components, biological monitoring, reproductive health counseling and alternative duty policies, training and competency assessment requirements, documentation and record-keeping, non-antineoplastic hazardous drug considerations, home administration guidance, and quality assurance.

Safe Handling of Hazardous Drugs — Part 3: Spill Management, Waste Disposal, and Decontamination

Spill classification and step-by-step response procedures, spill kit contents, personnel exposure management during spills, hazardous drug waste segregation and disposal, and surface decontamination protocols including deactivation, decontamination, and cleaning agents.

Safe Handling of Hazardous Drugs — Part 2: Personal Protective Equipment and Safe Handling Procedures

Complete PPE specifications for hazardous drug handling by activity type, including glove, gown, eye/face, and respiratory protection requirements; detailed procedures for receiving, storage, compounding, administration, patient care, and transport.

Safe Handling of Hazardous Drugs — Part 1: Drug Identification, Risk Assessment, and Engineering Controls

Hazardous drug definitions, NIOSH classification criteria, national drug list organization, exposure routes and health effects, facility risk assessment, and complete engineering control specifications including BSCs, CACIs, CSTDs, and ventilation requirements.