Transfusion Practice in Critical Care: A Comprehensive Clinical Guideline

Evidence-based guideline for red cell, platelet, plasma, and cryoprecipitate transfusion, massive transfusion protocols, transfusion reactions, and patient blood management in the critically ill.

4 articles • Updated Mar 2026

Transfusion in Critical Care — Part 4: Transfusion Reactions, Safety & Patient Blood Management

Recognition and management of all transfusion reactions (hemolytic, FNHTR, allergic, TRALI, TACO), TRALI vs TACO differential table, reporting requirements, patient blood management (PBM), special populations including Jehovah's Witness patients, and quality metrics.

guidelines•Mar 2026•guidelines

Transfusion in Critical Care — Part 3: Massive Transfusion & Hemorrhage Management

Massive transfusion protocol activation, fixed-ratio transfusion (1:1:1 per PROPPR), TEG/ROTEM viscoelastic testing and interpretation, damage control resuscitation, TXA (CRASH-2), calcium replacement, permissive hypotension, and hemorrhage management in trauma, obstetric, and GI bleeding.

guidelines•Mar 2026•guidelines

Transfusion in Critical Care — Part 2: Platelet, Plasma & Cryoprecipitate Transfusion

Evidence-based indications, thresholds, and dosing for platelet, plasma (FFP/FP24), and cryoprecipitate/fibrinogen concentrate transfusion, including platelet refractoriness, warfarin reversal, and special considerations for HIT, TTP, ITP, and DIC.

guidelines•Mar 2026•guidelines

Transfusion in Critical Care — Part 1: Red Blood Cell Transfusion

Evidence-based hemoglobin thresholds for RBC transfusion in the critically ill, landmark trial evidence (TRICC, TRISS, FOCUS, TITRe2, TRICS-III), physiologic triggers, single-unit policy, compatibility testing, and storage considerations.

guidelines•Mar 2026•guidelines