Sepsis and Septic Shock: A Comprehensive Clinical Management Guideline

Evidence-based guideline for screening, resuscitation, hemodynamic management, antimicrobial therapy, and organ support in sepsis and septic shock, synthesized from international critical care recommendations.

5 articles • Updated Mar 2026

Sepsis and Septic Shock — Part 5: Special Populations, Quality Metrics & Long-Term Outcomes

Sepsis management in immunocompromised patients, elderly, and pregnancy; bundle compliance and quality metrics; post-sepsis syndrome; long-term outcomes and performance improvement.

guidelines•Mar 2026•guidelines

Sepsis and Septic Shock — Part 4: Corticosteroids & Organ Support

Corticosteroid indications and evidence in septic shock, mechanical ventilation in sepsis-induced ARDS, renal replacement therapy, blood product management, glucose management, DVT and stress ulcer prophylaxis, and nutrition.

guidelines•Mar 2026•guidelines

Sepsis and Septic Shock — Part 3: Antimicrobial Therapy & Source Control

Timing of antibiotics, empiric broad-spectrum regimens by suspected source, de-escalation, duration of therapy, procalcitonin-guided discontinuation, antifungal considerations, and source control procedures.

guidelines•Mar 2026•guidelines

Sepsis and Septic Shock — Part 2: Initial Resuscitation & Hemodynamic Management

Hour-1 bundle components, fluid resuscitation strategy, crystalloid selection, fluid responsiveness assessment, vasopressor selection and dosing, inotrope use, hemodynamic monitoring, and lactate-guided resuscitation.

guidelines•Mar 2026•guidelines

Sepsis and Septic Shock — Part 1: Definitions, Screening & Early Identification

Sepsis-3 definitions, SOFA and qSOFA scoring, septic shock criteria, comparison with SIRS/Sepsis-2, and screening tools (NEWS, MEWS, qSOFA, SIRS) with sensitivity and specificity data.

guidelines•Mar 2026•guidelines