Acute Kidney Injury and Renal Replacement Therapy in Critical Care: A Comprehensive Clinical Guideline

Evidence-based guideline for AKI staging, prevention, conservative management, renal replacement therapy modalities, CRRT prescription, and special populations in the critically ill.

5 articles • Updated Mar 2026

Acute Kidney Injury — Part 5: Special Populations & Long-Term Outcomes

Sepsis-associated AKI, cardiac surgery-associated AKI, contrast-associated AKI, hepatorenal syndrome, rhabdomyolysis, tumor lysis syndrome, AKI in pregnancy, long-term outcomes, CKD progression, nephrology referral criteria, and quality metrics.

guidelines•Mar 2026•guidelines

Acute Kidney Injury — Part 4: Renal Replacement Therapy — Modalities, Timing & Prescription

RRT modalities comparison (IHD, CRRT, SLED/PIRRT), timing evidence (STARRT-AKI, AKIKI, IDEAL-ICU, ELAIN), CRRT prescription and dose, citrate and heparin anticoagulation protocols, vascular access, troubleshooting, and discontinuation criteria.

guidelines•Mar 2026•guidelines

Acute Kidney Injury — Part 3: Conservative Management of AKI Complications

Fluid management, hyperkalemia emergency algorithm, electrolyte and acid-base management, diuretic therapy including furosemide stress test, drug dosing in AKI, and nutritional considerations.

guidelines•Mar 2026•guidelines

Acute Kidney Injury — Part 2: Etiology, Diagnostic Workup & Prevention

Pre-renal, intrinsic, and post-renal AKI causes; diagnostic workup including urinalysis, FENa, FEUrea, and imaging; prevention strategies; nephrotoxin avoidance; contrast-associated AKI evidence; drug dose adjustment table.

guidelines•Mar 2026•guidelines

Acute Kidney Injury — Part 1: Definition, Staging & Epidemiology

KDIGO AKI definition and staging criteria, RIFLE and AKIN historical comparison, novel biomarkers (NGAL, KIM-1, NephroCheck), subclinical AKI, ICU epidemiology, and outcomes by stage.

guidelines•Mar 2026•guidelines