Traumatic Brain Injury: A Comprehensive Clinical Management Guideline

Evidence-based guideline for classification, imaging decisions, ICP management, surgical indications, and outcome prediction in traumatic brain injury across all severity levels.

5 articles Updated Mar 2026

Traumatic Brain Injury — Part 5: Concussion, Special Populations & Prognosis

Concussion assessment (SCAT6), return-to-play and return-to-learn protocols, post-concussive syndrome, pediatric TBI, geriatric TBI, TBI in pregnancy, IMPACT and CRASH prognostic models, biomarkers (GFAP, UCH-L1, S100B, NSE), and rehabilitation referral criteria.

Traumatic Brain Injury — Part 4: Specific Injury Types, Herniation & Advanced Monitoring

Epidural hematoma, acute and chronic subdural hematoma, traumatic subarachnoid hemorrhage, diffuse axonal injury, skull fractures, penetrating TBI, cerebral herniation syndromes, and advanced neuromonitoring including PbtO2, cerebral microdialysis, continuous EEG, and transcranial Doppler.

Traumatic Brain Injury — Part 3: ICP Management & Surgical Indications

ICP monitoring indications, ICP and CPP targets, complete tiered ICP management protocol with dosing, hyperosmolar therapy, EVD drainage, decompressive craniectomy (DECRA, RESCUEicp), barbiturate coma, and surgical indications for epidural hematoma, subdural hematoma, depressed skull fracture, and posterior fossa lesions.

Traumatic Brain Injury — Part 2: Initial Management & Resuscitation

Airway management and RSI in TBI, oxygenation and ventilation targets, blood pressure management, seizure prophylaxis, coagulopathy reversal, TXA (CRASH-3), and cerebral herniation emergency management.

Traumatic Brain Injury — Part 1: Classification & CT Imaging Decision Rules

GCS scoring, TBI severity classification, Canadian CT Head Rule, New Orleans Criteria, PECARN pediatric head CT algorithm, and comparison of imaging decision rules with sensitivity and specificity data.