Trauma Primary and Secondary Survey — Part 2: Adjuncts to Primary Survey, Secondary Survey & Hemorrhagic Shock

Extended FAST technique, chest and pelvis radiography, Foley and NG tube placement, complete head-to-toe secondary survey, AMPLE history, and hemorrhagic shock classification with Classes I-IV.

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1. Adjuncts to the Primary Survey

Adjuncts to the primary survey are diagnostic and therapeutic interventions performed concurrently with or immediately following the ABCDE assessment. They provide additional information to guide resuscitation and disposition decisions.1 2

1.1 Extended FAST (eFAST)

The eFAST expands the standard four-view FAST examination by adding bilateral anterior thoracic views to detect pneumothorax. The eFAST is performed during the primary survey and has largely replaced the initial supine chest radiograph as the first-line screening test for pneumothorax and hemothorax in many trauma centers.1 3

eFAST Protocol — Six Views

ViewProbe PositionWhat It DetectsTechnique Notes
1. Right upper quadrant (RUQ)Right flank, coronal plane between 9th-11th ribs at the posterior axillary lineFree fluid in Morrison’s pouch (hepatorenal recess); right pleural effusion/hemothorax (above diaphragm)Morrison’s pouch is the most sensitive single view for free abdominal fluid in the supine patient; always fan superiorly to evaluate for right hemothorax above the diaphragm
2. Left upper quadrant (LUQ)Left flank, coronal plane between 8th-11th ribs at the posterior axillary lineFree fluid in the splenorenal recess and left subphrenic space; left hemothoraxFan superiorly above the spleen — the left subphrenic space is a common location for free fluid; left-sided fluid may collect superior to the spleen rather than in the splenorenal recess
3. SuprapubicTransverse and sagittal planes just superior to the pubic symphysisFree fluid in the pelvis (rectovesical pouch in males; Pouch of Douglas in females)The bladder serves as an acoustic window; a full bladder improves sensitivity; scan in both transverse and sagittal planes
4. SubxiphoidSubxiphoid, angled toward the left shoulderPericardial effusion/hemopericardiumIf the subxiphoid view is inadequate (e.g., due to abdominal distension, subcutaneous emphysema), use the parasternal long-axis view as an alternative
5. Right anterior chestAnterior chest wall, 2nd-4th ICS at midclavicular line, bilaterallyPneumothoraxNormal: “sliding sign” (pleural sliding) and “comet tail artifacts” (B-lines) indicate lung apposition to chest wall; Absent sliding + absent B-lines + “barcode sign” (M-mode) = pneumothorax; “Lung point” (transition between sliding and non-sliding pleura) confirms pneumothorax and indicates its extent
6. Left anterior chestAnterior chest wall, 2nd-4th ICS at midclavicular linePneumothoraxSame technique as right; always examine both sides

eFAST Performance Characteristics

ConditionSensitivitySpecificityNotes
Free abdominal fluid (hemoperitoneum)73-88%95-100%Sensitivity improves with operator experience and serial exams; minimum detectable volume approximately 200-500 mL
Pericardial effusion90-100%95-99%Very high sensitivity for significant hemopericardium
Pneumothorax86-98%97-100%Superior to supine chest radiograph (sensitivity 28-75%); comparable to CT
Hemothorax92-96%95-100%Detects as little as 100-200 mL of pleural fluid

eFAST Limitations

  • Operator dependent — performance varies with training and experience
  • False negatives — most commonly occur with:
    • Small amounts of free fluid (< 200 mL)
    • Retroperitoneal hemorrhage (not visible on FAST)
    • Hollow viscus injury without significant free fluid
    • Isolated solid organ injury with intact capsule (contained hematoma)
    • Obesity, subcutaneous emphysema (degrades image quality)
    • Pelvic fracture blood contained in retroperitoneum
  • False positives — pre-existing ascites, physiologic free fluid, pericardial fat pad mimicking effusion
  • Does not identify the specific organ injured — a positive FAST identifies free fluid but does not localize the source

1.2 Chest Radiograph

A portable anteroposterior (AP) supine chest radiograph is obtained during the primary survey in all major trauma patients. It can be performed simultaneously with the primary survey without interrupting resuscitation.1 2

Findings to evaluate systematically:

FindingClinical Significance
PneumothoraxMay be missed on supine film; look for deep sulcus sign, increased lucency at costophrenic angle
HemothoraxOpacification of the hemithorax; may require > 200-300 mL to be visible on supine film
Mediastinal wideningWidth > 8 cm or mediastinal-to-chest width ratio > 0.25 suggests aortic injury; loss of aortic knob, deviation of NG tube to the right, left apical cap, depression of left mainstem bronchus
Rib fracturesFirst and second rib fractures suggest high-energy mechanism (associated with great vessel injury); lower rib fractures (9-12) associated with hepatic and splenic injury
Diaphragm ruptureElevated hemidiaphragm, bowel gas pattern in the chest (usually left-sided)
Tracheal/bronchial deviationMay indicate tension pneumothorax, massive hemothorax, or airway injury
Subcutaneous emphysemaSuggests pneumothorax, airway injury, or esophageal injury
ET tube positionVerify 2-4 cm above the carina

1.3 Pelvic Radiograph

An anteroposterior (AP) pelvis radiograph is obtained in the primary survey of all patients with blunt trauma and clinical suspicion of pelvic fracture (mechanism of injury, pelvic tenderness, instability on examination, or hemodynamic instability).1 2

Key findings:

  • Pubic symphysis diastasis (> 2.5 cm suggests disruption of the pelvic ring)
  • Sacroiliac joint widening
  • Fracture patterns: anterior-posterior compression (open-book), lateral compression, vertical shear
  • A pelvic binder should already be in place before the radiograph if clinical suspicion is high

Note: In hemodynamically stable patients undergoing CT, the pelvic radiograph may be deferred in favor of the CT scan, which provides more detailed information. However, in unstable patients, the AP pelvis film is a rapid screening tool.

1.4 Foley Catheter

Placement of an indwelling urinary (Foley) catheter is performed during or immediately after the primary survey to:1

  • Monitor urine output as an indicator of renal perfusion and resuscitation adequacy (target: 0.5 mL/kg/hr in adults; 1 mL/kg/hr in children; 2 mL/kg/hr in infants < 1 year)
  • Decompress the bladder before abdominal assessment or operative intervention
  • Assess for gross hematuria (indicating urinary tract injury)

Contraindications to urethral catheter placement (perform retrograde urethrogram first):

FindingSignificance
Blood at the urethral meatusSuggests urethral injury
Perineal hematoma (butterfly hematoma)Suggests urethral injury
High-riding or non-palpable prostate on digital rectal examSuggests posterior urethral disruption (associated with pelvic fracture)
Scrotal hematomaAssociated with urethral/perineal injury
Pelvic fracture with any of the above signsHigh risk of urethral injury

If urethral injury is suspected, a retrograde urethrogram (RUG) should be performed before catheter insertion. If urethral injury is confirmed, a suprapubic catheter is placed instead.

1.5 Gastric Tube (Nasogastric or Orogastric)

Placement of a gastric tube is performed to:1

  • Decompress the stomach (reduces risk of aspiration, facilitates abdominal examination and ventilation)
  • Assess for upper GI hemorrhage (blood in gastric aspirate)

Route selection:

RouteIndicationContraindication
Nasogastric (NG)Default route in most patientsSuspected basilar skull fracture (risk of intracranial placement through the cribriform plate); severe midface fractures
Orogastric (OG)Patients with suspected basilar skull fracture or midface fractures; intubated patientsAwake patients with intact gag reflex (may cause vomiting)

1.6 Additional Adjuncts

AdjunctPurpose
Continuous cardiac monitoringDetect arrhythmias (cardiac contusion, tension pneumothorax causing PEA, hyperkalemia)
Arterial blood gas (ABG)Assess ventilation (PaCO2), oxygenation (PaO2), and acid-base status (pH, base deficit, lactate)
Base deficitMarker of tissue hypoperfusion; base deficit > 6 mEq/L indicates significant shock; > 10 mEq/L indicates severe shock
LactateMarker of anaerobic metabolism due to hypoperfusion; initial lactate > 4 mmol/L associated with increased mortality; serial lactate clearance guides resuscitation adequacy
Complete blood countBaseline hemoglobin/hematocrit (may be normal early in acute hemorrhage due to hemoconcentration); platelet count
Type and crossmatchEssential for blood product administration; send immediately on arrival for all major trauma
Coagulation studiesPT/INR, PTT, fibrinogen — establish baseline coagulopathy; fibrinogen < 150-200 mg/dL in hemorrhaging patient warrants cryoprecipitate
Comprehensive metabolic panelElectrolytes, renal function, hepatic enzymes (elevated AST/ALT may suggest hepatic injury)
Pregnancy testAll females of reproductive age (12-55 years); urine or serum beta-hCG
Toxicology screenBlood alcohol level and urine drug screen in patients with altered mental status (alcohol and drugs may confound neurologic assessment)
TEG/ROTEMViscoelastic hemostatic assays for goal-directed transfusion (detailed in Part 3)

2. Secondary Survey

2.1 Principles

The secondary survey is a comprehensive, systematic head-to-toe examination performed only after the primary survey is complete, resuscitation is underway, and the patient has demonstrated normalization of vital functions or is stable enough for a thorough evaluation. If the patient deteriorates at any point during the secondary survey, return immediately to the primary survey (ABCDE).1 2

The secondary survey consists of:

  1. A complete history (AMPLE)
  2. A thorough head-to-toe physical examination
  3. A complete neurologic examination
  4. Appropriate diagnostic studies (CT, additional radiographs, laboratory work)

2.2 AMPLE History

The AMPLE mnemonic provides a structured framework for obtaining the essential elements of the trauma patient’s history. This information is obtained from the patient (if able to communicate), prehospital providers, family members, medical records, or medical alert identification.1

LetterComponentDetails to Obtain
AAllergiesDrug allergies (especially antibiotics, anesthetics, contrast dye, latex); type of reaction (anaphylaxis vs. intolerance)
MMedicationsCurrent medications including prescription, over-the-counter, and supplements; critical: anticoagulants (warfarin, DOACs — apixaban, rivarelbaan, edoxaban, dabigatran), antiplatelet agents (aspirin, clopidogrel, ticagrelor, prasugrel), beta-blockers (may blunt tachycardic response to hemorrhage), insulin/oral hypoglycemics
PPast medical/surgical historyComorbidities (cardiovascular, pulmonary, hepatic, renal, immunosuppression, diabetes); prior surgeries (especially abdominal — adhesions may complicate operative management); pregnancy status and gestational age
LLast meal / Last menstrual periodTime of last oral intake (relevant for aspiration risk during intubation); last menstrual period (pregnancy status)
EEvents / Environment related to injuryMechanism of injury (blunt vs. penetrating, speed, height of fall, weapon type); scene description (extrication time, death of other occupants, damage to vehicle); prehospital vital signs and interventions; restraint use, airbag deployment, helmet use

2.3 Head-to-Toe Physical Examination

The secondary survey physical examination proceeds systematically from head to toe. Every region of the body is examined by inspection, palpation, and auscultation as appropriate.1 2

2.3.1 Head and Face

ExaminationFindings Sought
ScalpLacerations (scalp lacerations can cause significant hemorrhage due to rich blood supply — control with direct pressure, Raney clips, or running locked suture); hematomas; depressed or open skull fractures (palpable step-off, crepitus)
FaceMidface instability (Le Fort fractures — grasp maxilla and assess for mobility); mandible fractures (palpate along inferior border, assess dental occlusion); orbital rim fractures; zygomatic fractures
EyesVisual acuity (even a gross assessment — counting fingers, light perception); pupil size and reactivity (reassessed from primary survey); extraocular movements (entrapment suggests orbital floor fracture); globe rupture (irregular pupil, shallow anterior chamber, extruded intraocular contents — if suspected, do NOT apply pressure, place protective eye shield)
EarsHemotympanum (blood behind the tympanic membrane — suggests basilar skull fracture); CSF otorrhea (clear fluid from the ear); Battle sign (postauricular ecchymosis — develops over hours, suggests temporal bone/basilar skull fracture)
NoseCSF rhinorrhea (clear fluid from the nose — test with “halo/ring sign” on gauze: CSF separates from blood to form a clear ring; or test for beta-2 transferrin); epistaxis; nasal septal hematoma (must be drained to prevent septal necrosis and saddle-nose deformity)

2.3.2 Neck

ExaminationFindings Sought
With anterior collar removed and MILS maintained
InspectionPenetrating wounds (any wound that penetrates the platysma requires surgical consultation); expanding hematoma; tracheal deviation; JVD
PalpationCervical spine tenderness (midline and paraspinal); step-off deformity; subcutaneous emphysema; tracheal position; carotid pulses (do NOT palpate both simultaneously)
LarynxHoarseness, voice change, palpable fracture crepitus (suggests laryngeal injury — requires emergent evaluation)

2.3.3 Chest

ExaminationFindings Sought
InspectionContusions, abrasions (“seatbelt sign” — ecchymosis across the chest suggests deceleration injury); paradoxical movement; open wounds; asymmetric expansion
PalpationRib tenderness, crepitus, flail segment; sternal tenderness/instability; subcutaneous emphysema
AuscultationBilateral breath sounds (reassessment); cardiac sounds (muffled heart sounds may suggest cardiac tamponade)
PercussionHyperresonance (pneumothorax); dullness (hemothorax)

2.3.4 Abdomen

ExaminationFindings Sought
InspectionDistension; contusions; abrasions; seatbelt sign (ecchymosis across the lower abdomen — associated with mesenteric and hollow viscus injury in up to 20-30% of patients); penetrating wounds (mark all wounds; do not explore or probe)
PalpationTenderness (may be unreliable in patients with altered mental status, distracting injuries, or intoxication); guarding; rigidity (peritoneal signs); hepatic/splenic tenderness
AuscultationBowel sounds (absence is nonspecific but may indicate ileus or peritoneal irritation)
NoteThe abdominal examination in the multi-injured patient is frequently unreliable. A high index of suspicion must be maintained, and adjunctive studies (FAST, CT) are essential in all patients with significant mechanism. Serial abdominal examinations are critical in patients managed non-operatively.

2.3.5 Pelvis

ExaminationFindings Sought
InspectionPerineal hematoma; vaginal or rectal bleeding; limb length discrepancy; rotational deformity
PalpationGently assess pelvic stability with a single attempt at lateral-to-medial compression and anterior-posterior compression of the iliac wings; do NOT repeatedly “spring” the pelvis as this may disrupt clot and worsen hemorrhage
Digital rectal examHigh-riding prostate (urethral disruption); gross blood (GI injury); rectal tone (spinal cord injury) — note: the routine digital rectal exam in trauma is increasingly being questioned for its diagnostic yield and may be omitted in many cases
Vaginal examIn patients with pelvic fractures — assess for vaginal laceration (open pelvic fracture), which changes management

2.3.6 Extremities

ExaminationFindings Sought
InspectionDeformity, swelling, ecchymosis, open fractures (Gustilo classification), amputations, crush injuries
PalpationTenderness, crepitus, instability, compartment firmness (tense, painful compartments suggest compartment syndrome)
Vascular assessmentPalpation of distal pulses (dorsalis pedis, posterior tibial, radial, ulnar); capillary refill; ankle-brachial index (ABI) — an ABI < 0.9 warrants further vascular evaluation; absent or diminished pulses require emergent vascular assessment
NeurologicMotor and sensory function distal to each injury; compare bilaterally
JointsRange of motion, stability, effusion

2.3.7 Back and Spine (Log Roll)

The patient is log-rolled with cervical spine immobilization maintained to examine the posterior surface:1

ExaminationFindings Sought
InspectionWounds, contusions, deformities of the thoracic and lumbar spine
PalpationThoracic and lumbar spinous process tenderness; step-off deformity; paraspinal muscle spasm; flank tenderness (renal injury)
Gluteal/perineal inspectionWounds, hematomas
Rectal examIf not already performed (may be deferred; see above)
Remove backboardThe rigid backboard should be removed as early as possible (ideally within 30-60 minutes of arrival) to prevent pressure injury

2.4 Complete Neurologic Examination

The secondary survey neurologic examination expands on the disability assessment performed during the primary survey:1

ComponentAssessment
GCSReassess and document (should be post-resuscitation GCS)
Cranial nervesII through XII — pupillary response, extraocular movements, facial symmetry, gag reflex
MotorStrength in all extremities graded 0-5; document any lateralizing findings
SensoryLight touch, pain (pin-prick) in all dermatomes; document sensory level if spinal cord injury is suspected
ReflexesDeep tendon reflexes; Babinski sign (upgoing toe suggests upper motor neuron lesion); bulbocavernosus reflex (in suspected spinal cord injury — return of this reflex marks the end of spinal shock and allows prognosis of the neurologic injury)
Rectal toneIf spinal cord injury is suspected; absent rectal tone suggests complete spinal cord injury

3. Hemorrhagic Shock — Classification and Physiologic Response

3.1 Overview

Hemorrhagic shock is the most common cause of shock in the trauma patient. It is a state of inadequate organ perfusion and tissue oxygenation caused by acute blood loss. Rapid identification of the class of hemorrhage guides the aggressiveness of resuscitation and the urgency of hemorrhage control interventions.1 4 5

Estimated blood volume: Approximately 70 mL/kg in adults (approximately 5 liters in a 70-kg patient). Blood volume is proportionally higher in children (80 mL/kg) and infants (80-90 mL/kg).

3.2 Hemorrhagic Shock Classification — Classes I Through IV

The following classification system categorizes hemorrhage severity based on the estimated volume of blood loss and corresponding physiologic parameters. Note that these are guidelines — individual patient responses vary significantly based on age, comorbidities, medications (particularly beta-blockers), physical fitness, and rate of hemorrhage.1 4

ParameterClass IClass IIClass IIIClass IV
Estimated blood loss (mL)Up to 750750-1,5001,500-2,000> 2,000
Estimated blood loss (% blood volume)Up to 15%15-30%30-40%> 40%
Heart rate (bpm)< 100100-120120-140> 140 or bradycardia (preterminal)
Blood pressureNormalNormal (decreased pulse pressure due to increased diastolic from vasoconstriction)Decreased (SBP < 90 mmHg)Markedly decreased (SBP often < 70 mmHg)
Pulse pressureNormal or widenedNarrowedNarrowedNarrowed or undetectable
Respiratory rate14-2020-3030-40> 35 or agonal
Urine output (mL/hr)> 3020-305-15Negligible (anuria)
Mental statusSlightly anxiousMildly anxiousAnxious, confusedConfused, lethargic, obtunded
Capillary refillNormalDelayedDelayedAbsent
Base deficit (mEq/L)0 to -2-2 to -6-6 to -10< -10
Initial fluid/blood replacementCrystalloid (if any)CrystalloidCrystalloid + blood productsMassive transfusion protocol; emergent hemorrhage control

3.3 Important Caveats to the Classification System

The above classification represents a simplified model. In clinical practice, the following factors complicate the assessment of hemorrhagic shock:1 4 6

FactorImpact
AgeElderly patients have reduced physiologic reserve, blunted tachycardic response, and lower baseline blood volume; an SBP of 110 mmHg in a chronically hypertensive elderly patient may represent significant shock
MedicationsBeta-blockers prevent compensatory tachycardia; ACE inhibitors and ARBs impair vasoconstriction; anticoagulants worsen ongoing hemorrhage
AthletesTrained athletes have higher baseline blood volume, lower resting heart rate, and enhanced compensatory mechanisms; they may maintain normal vital signs despite significant blood loss
PregnancyPhysiologic hypervolemia of pregnancy (30-50% increase in blood volume by the third trimester) provides a buffer that may mask early hemorrhage; fetal distress may precede maternal hemodynamic compromise
ChildrenExcellent compensatory mechanisms; children maintain blood pressure until very late (decompensation occurs abruptly with > 30% volume loss); tachycardia and poor perfusion are the earliest signs
HypothermiaCauses bradycardia, impaired myocardial contractility, and coagulopathy; may mimic or worsen hemorrhagic shock
PacemakersFixed-rate pacemakers prevent tachycardic response
Rate of hemorrhageRapid hemorrhage may produce class IV shock with relatively smaller total volume loss because compensatory mechanisms have insufficient time to respond

3.4 Shock Index

The Shock Index (SI) = Heart Rate / Systolic Blood Pressure is a simple bedside tool that may be more sensitive than individual vital signs for detecting occult hemorrhagic shock.7

Shock IndexInterpretation
< 0.7Normal
0.7-1.0Compensated shock / borderline
1.0-1.5Moderate shock; likely significant hemorrhage; consider MTP
> 1.5Severe shock; high mortality risk; activate MTP
  • The SI has been validated as an early predictor of the need for massive transfusion and emergent intervention
  • Age-adjusted shock index (SI x age) may improve accuracy in elderly patients
  • Reverse Shock Index x GCS (rSIG) = GCS / SI; rSIG < 8 predicts massive transfusion requirement

3.5 Response to Initial Fluid Resuscitation

The patient’s response to the initial fluid challenge (typically 1 liter of warm isotonic crystalloid, or blood products if hemorrhage class III-IV) provides critical information about the severity and ongoing nature of hemorrhage:1 4

Response PatternDescriptionEstimated Blood LossManagement Implication
Rapid responderVital signs normalize and remain normal after initial fluid bolusUsually Class I-II (< 20%)Hemorrhage likely controlled; continue monitoring; may not require blood products or operative intervention
Transient responderVital signs initially improve but then deteriorate againUsually Class II-III (20-40%)Ongoing hemorrhage; blood products likely needed; surgical or angiographic hemorrhage control may be required
Non-responder (minimal/no response)Vital signs do not improve despite fluid resuscitationUsually Class III-IV (> 40%) OR non-hemorrhagic cause of shockOngoing life-threatening hemorrhage requiring emergent operative intervention and massive transfusion; OR consider non-hemorrhagic cause (tension pneumothorax, cardiac tamponade, cardiogenic, neurogenic shock)

3.6 Non-Hemorrhagic Causes of Shock in Trauma

While hemorrhagic shock is the most common cause of shock in the trauma patient, other etiologies must be considered, particularly when the patient does not respond as expected to volume resuscitation:1

Type of ShockMechanismKey FeaturesTreatment
Obstructive — Tension pneumothoraxImpaired venous return due to increased intrathoracic pressureAbsent breath sounds, hyperresonance, JVD (may be absent), tracheal deviation (late)Immediate needle/finger decompression followed by chest tube
Obstructive — Cardiac tamponadeImpaired ventricular filling due to pericardial bloodBeck’s triad (muffled heart sounds, JVD, hypotension) — complete triad present in < 40%; pulsus paradoxus; PEA arrest; positive FAST (pericardial fluid)Pericardiocentesis (temporizing) or emergency thoracotomy (definitive)
CardiogenicMyocardial contusion, myocardial infarction, valvular injuryHistory consistent with blunt chest trauma; dysrhythmias; elevated troponin; echocardiographic wall motion abnormalityInotropic support; treat underlying cause
NeurogenicLoss of sympathetic tone due to spinal cord injury (usually above T6)Hypotension with bradycardia (unlike hemorrhagic shock, which causes tachycardia); warm, flushed skin below the level of injury; neurologic deficitsVolume resuscitation; vasopressors (norepinephrine or phenylephrine); atropine for symptomatic bradycardia; MUST exclude hemorrhagic shock first — neurogenic shock is a diagnosis of exclusion
Septic (late presentation)Rare in acute trauma; consider in delayed presentations, open fractures, contaminated woundsFever, warm shock (early), cold shock (late); leukocytosisSource control, antibiotics, vasopressors

References


  1. American College of Surgeons Committee on Trauma. Advanced Trauma Life Support (ATLS) Student Course Manual, 10th ed. Chicago: American College of Surgeons; 2018. URL: https://www.facs.org/quality-programs/trauma/atls/ ↩︎ ↩︎ ↩︎ ↩︎ ↩︎ ↩︎ ↩︎ ↩︎ ↩︎ ↩︎ ↩︎ ↩︎ ↩︎ ↩︎ ↩︎ ↩︎

  2. National Institute for Health and Care Excellence. “Major Trauma: Assessment and Initial Management (NG39).” London: NICE; 2016 (updated 2023). URL: https://www.nice.org.uk/guidance/ng39 ↩︎ ↩︎ ↩︎ ↩︎ ↩︎

  3. Kirkpatrick AW, Sirois M, Laupland KB, et al. “Hand-Held Thoracic Sonography for Detecting Post-Traumatic Pneumothoraces: The Extended Focused Assessment with Sonography for Trauma (EFAST).” J Trauma. 2004;57(2):288-295. DOI: 10.1097/01.TA.0000133565.88871.E4 ↩︎

  4. Mutschler M, Nienaber U, Brockamp T, et al. “A Critical Reappraisal of the ATLS Classification of Hypovolaemic Shock: Does It Really Reflect Clinical Reality?” Resuscitation. 2013;84(3):309-313. DOI: 10.1016/j.resuscitation.2012.07.012 ↩︎ ↩︎ ↩︎ ↩︎

  5. Cannon JW. “Hemorrhagic Shock.” N Engl J Med. 2018;378(4):370-379. DOI: 10.1056/NEJMra1705649 ↩︎

  6. Guly HR, Bouamra O, Spiers M, et al. “Vital Signs and Estimated Blood Loss in Patients with Major Trauma: Testing the Validity of the ATLS Classification of Hypovolaemic Shock.” Resuscitation. 2011;82(5):556-559. DOI: 10.1016/j.resuscitation.2011.01.013 ↩︎

  7. Mutschler M, Nienaber U, Munzberg M, et al. “The Shock Index Revisited — A Fast Guide to Transfusion Requirement? A Retrospective Analysis on 21,853 Patients Derived from the TraumaRegister DGU.” Crit Care. 2013;17(4):R172. DOI: 10.1186/cc12851 ↩︎