Toxicology and Overdose Management: A Comprehensive Emergency Guideline

Evidence-based guideline for recognition, decontamination, specific antidote therapy, and enhanced elimination in acute poisoning and overdose presentations.

5 articles • Updated Mar 2026

Toxicology and Overdose Management — Part 5: Pediatric Poisoning, Antidote Reference Table, Toxicologic Cardiac Arrest & Substance Abuse Emergencies

One pill can kill agents, weight-based pediatric antidote dosing, comprehensive antidote dosing reference table, toxicologic cardiac arrest management by agent, alcohol withdrawal protocols, synthetic cannabinoids, novel psychoactive substances, and poison center consultation guidance.

guidelines•Mar 2026•guidelines

Toxicology and Overdose Management — Part 4: Toxic Alcohols, Metals, Organophosphates, Environmental & Chemical Poisonings

Complete management of methanol and ethylene glycol poisoning (fomepizole, hemodialysis), carbon monoxide, cyanide, organophosphates and nerve agents, iron poisoning, caustic ingestions, local anesthetic systemic toxicity (LAST), sympathomimetic toxicity, and enhanced elimination techniques including urinary alkalinization and EXTRIP hemodialysis indications.

guidelines•Mar 2026•guidelines

Toxicology and Overdose Management — Part 3: Cardiovascular Drug, Antidepressant & Psychotropic Poisonings

Complete management of TCA poisoning (sodium bicarbonate protocol), calcium channel blocker overdose (high-dose insulin), beta-blocker toxicity, digoxin poisoning (DigiFab), serotonin syndrome, neuroleptic malignant syndrome, lithium toxicity, and antipsychotic overdose.

guidelines•Mar 2026•guidelines

Toxicology and Overdose Management — Part 2: Analgesic, Opioid, Benzodiazepine & Sedative Poisonings

Complete management of acetaminophen overdose (NAC protocols), salicylate poisoning (alkalinization, hemodialysis), opioid overdose (naloxone titration), benzodiazepine reversal (flumazenil), and sedative-hypnotic poisonings.

guidelines•Mar 2026•guidelines

Toxicology and Overdose Management — Part 1: General Approach, Toxidrome Recognition & GI Decontamination

Initial approach to the poisoned patient including toxidrome recognition, diagnostic workup, toxicology screen interpretation, and gastrointestinal decontamination strategies including activated charcoal, whole bowel irrigation, gastric lavage, and multi-dose activated charcoal.

guidelines•Mar 2026•guidelines