SSC 2026 Guidelines now available — 129 adult & 61 pediatric recommendations View guidelines →
Evidence-based guideline for prevention, recognition, and management of chemotherapy extravasation injuries, including agent classification, antidote protocols, and follow-up care.
Surgical consultation criteria, wound grading, patient follow-up protocols, peripheral vs. central line extravasation management, documentation requirements, incident reporting, legal considerations, staff competency assessment, and institutional protocol development.
Signs and symptoms of extravasation (early and late), differential diagnosis, step-by-step immediate management algorithm, specific antidote protocols with complete dosing for dexrazoxane, hyaluronidase, sodium thiosulfate, and DMSO, and thermal management by agent class.
Complete classification of antineoplastic agents by tissue damage potential (vesicants, irritants, non-vesicants), comprehensive risk factor analysis, and evidence-based prevention strategies including vein selection, device selection, and monitoring protocols.
Complete guide to IV infiltration and extravasation: infiltration staging scale (0–4), vesicant vs. non-vesicant injury, antidote table (dexrazoxane, hyaluronidase, phentolamine), emergency response, and prevention.